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The involvement of GLP-1 in PD can be simplified to the activation of the MAPK/extracellular signal-regulated kinase 1/2 (ERK) pathway, which has an important role in synaptic plasticity, and the PI3K/Akt pathway signaled by GLP-1 receptor stimulation and the subsequent increase in cAMP and PKA and PI3K activation [73]
Girnita is the founder of Rheumatologist OnCall , the first nationwide telehealth rheumatology practice in the United States, providing patient care across 20+ states with no referral required
Additionally, dulaglutide reduced the production of pro-inflammatory molecules monocyte chemoattractant protein-1 (MCP-1), IL-6 and IL-1 in FLSs, underscoring its strong anti-inflammatory properties [241]
Personalized care models can address these gaps with regular check-ins, side effect education, and real-time support that help GLP-1 users stay informed and on track
