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Levels decline with age, dropping significantly after 20

Also important for endochondral ossification (cartilage-to-bone conversion during fracture healing)

doi: 10.1080/09537100903047752 99 KeepR

While research is still developing, several groups may find it worthwhile at doses considered safe (2g or less per day): People with liver concerns Clinical studies show TUDCA can improve liver enzyme markers and bile flow in conditions like NAFLD and PBC.4 31 Benefits seem strongest in people who already have elevated enzymes or bile duct issues, rather than in generally healthy adults

As for people who should not use epitalon, we know that this group includes women who are pregnant or breastfeeding , as there isnt enough research to confirm the safety of the mother, their fetus, or their developing child