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Synaptic impairment is thought to occur early in the neurodegenerative process across a range of pathologies and may result from a complex combination of pathologic mechanisms including toxic amyloid beta and tau oligomers (Gutierrez and Limon, 2022

Moreno also wondered about what kind of "off ramp" would be offered to patients who want to stop taking the medication during the subscription period

There are also some rare instances of ones with less than these

But the headline numbers undersell whats really happening here

One of the major secondary effects of AKT activation is the stimulation of the mammalian target of rapamycin complex 1 (mTORC1), a nutrient-loaded sensor complex that stimulates lipid production (125, 126)