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Therefore, the development of novel, safer, and more effective therapies for the clinical management of women with PCOS and their metabolic complications remains an unmet medical need

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A similar beneficial association was seen in an observational study of semaglutide in 83,825 patients with obesity and 598,803 patients with T2DM over 12 months 112 , as well as in 87,676 new users of GLP-1RAs or DPP-4 inhibitors over 4 years 113

Drug therapy for weight loss has made significant progress

"Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis: Rationale and design of the TRIUMPH registrational clinical trials." Diabetes, Obesity and Metabolism , 2026;28(1):83-93