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10.3389/fphys.2017.00428 162 ShiJ.YuJ.PohorlyJ

Her evaluation involves a thorough medical history and physical exam, and even some genetic or lab testing to understand any metabolic or health conditions

The decline of NAD + with age results from three converging factors: (1) increased activity of CD38, a NADase whose expression increases with age-related chronic inflammation (inflammaging), (2) reduced biosynthesis via the NAMPT (nicotinamide phosphoribosyltransferase) and NMN pathways, and (3) increased demand for NAD+ by PARP-1 to repair increasing oxidative DNA damage

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