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Funding This work was supported by the National Natural Science Foundation of China [81970023], the Shanghai Top-Priority Clinical Key Disciplines Construction Project [2017ZZ02013], the Shanghai Municipal Key Clinical Specialty [shslczdzk02201], and the Youth Fund of Zhongshan Hospital [2021-015]

7d), confirming that the need to increase mitochondrial mass in 5FU-treated cells is driven by a dependence on increased mitochondrial activity, and metformin can block this mitochondrial adaptation to prevent drug tolerance in tumours

Who develops adult ADHD