In the UK between 2007 and October 2025, the MHRA has received 1,296 Yellow Card reports of pancreatitis (including acute, autoimmune, chronic, haemorrhagic, necrotising, subacute and obstructive forms of pancreatitis) associated with GLP-1 receptor agonists or dual GLP-1/GIP receptor agonists
Kumar, P., Shenoi, R.A., Lai, B.F., Nguyen, M., Kizhakkedathu, J.N., and Straus, S.K., Biomacromolecules , 2015, vol
Descriptions of doses refer to clinical-trial and laboratory research settings only
However, we did not observe significant differences in circulating IGF-1 levels with mAb treatment in older mice, though levels tended to be higher in mAb-treated females, but glucose homeostasis was not adversely affected in either sex, suggesting minimal disruption of the somatotropic axis in this older cohort of mice
They also emphasize that additional randomized clinical trials involving broader populations and longer follow-up periods will be important for confirming these findings and evaluating their generalizability