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The trial in people with T2D included 281 participants (mean age 56 years, 56% women, mean BMI 35.0 kg/m 2 , mean HbA1c 8.3%) treated with lifestyle only and/or metformin, with similar intervention arms to the obesity trial, albeit retatrutide 0.5 mg rather than 1 mg, and dulaglutide 1.5 mg was an additional comparator [46]

Because both peptides promote angiogenesis (new blood vessel growth), they are strictly contraindicated for anyone with an active malignancy or a history of cancer

For further details of the protocol please see Katre et al

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Modulation is typically mild but significant in the setting of hyperprolactinemia