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You would increase the risk and severity of side effects, including serious side effects, and might lose weight too quickly

The early evidence In November, a major trial showed that semaglutide lowered the risk of events like heart attacks and strokes by 20 percent among obese and overweight people with heart disease

Consistent with this notion, liver disease progression is associated not only with an increased risk of liver-related adverse outcomes from hepatic decompensation and hepatocellular carcinoma (HCC), but also increased all-cause, cardiovascular and extrahepatic cancer-related mortality, which are the leading causes of death in patients with MAFLD/MASH [2]

Second, it can simply be inconvenient

If you experience sharp pain during the injection, it may indicate needle contact with muscle or a nerve