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Foundayo (Orforglipron) As the latest addition to GLP-1 weight loss medications, Foundayo was approved in April 2026

Preoperative Medication Management Framework Safe semaglutide management before surgery involves coordination across three teams: your primary prescriber, your surgeon, and your anesthesiologist

Given the known role of Y1-R in GLP-1R-mediated regulation of insulin secretion, we were surprised to find that Y1-R also stimulated glucose uptake in muscle via a mechanism that was fully independent of insulin stimulation

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Many therapies now considered foundational in perioperative medicine were initially adopted based on mechanistic plausibility and early observational signals before high-quality surgical outcome trials were performed