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Recommending unapproved treatments undermines this principle and puts patients at unnecessary risk

COPD is increasingly being recognized as a multicomponent disorder, and its severity can increase due to comorbidities

157,158,159,160,161,162 The effect of PARPs to stimulate chromatin decompaction might be exerted via the steric hindrance of PAR chain, the negative charge of DNA and PAR, or the displacement of core histones

Metabolic balance: May help regulate blood sugar and energy production

Despite the identification of many potential targets of antioxidant therapy, and abundant pre-clinical data, few antioxidant agents have undergone formal trials to assess clinical benefit in COPD