The glutathione conjugate is subsequently secreted from the cell [36]
However, extremely high doses can lead to complications, especially in individuals with certain medical conditions
96116 Neurobehavioral status exam
In a pilot study, patients given high-dose NAC for 4 weeks successfully returned their brain glutathione and oxidative stress levels to normal, alongside an amelioration of ME/CFS symptoms
Selected Publications Keklikoglou, I., CIanciaruso, C., Guc, E., Squadrito, M.L., Spring, L.M., Tazzyman, S., Lambien, L., Poissonnier, A., Ferraro, G.B., Baer, C., Cassara, A., Guichard, A., Iruela-Arispe, M.L., Lewis, C.E., Coussens, L.M., Bardia, A., Jain, R.K., Pollard, J.W., De Palma, M., "Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models", Nature Cell Biol (2018)