It is studied for interaction with GLP-1, GIP, and glucagon receptor pathways
Those with severe pancreatitis, diabetic retinopathy, or severe kidney disease require careful evaluation before starting therapy
Reusch J, Stewart MW, Perkins CM, Cirkel DT, Ye J, Perry CR, et al
When blood sugar levels drop quickly, it can lead to changes in blood flow that may predispose certain individuals to ischemic damage in the optic nerve
Beyond that, the supplements guide for GLP-1 users recommends considering: Electrolytes: Especially during the first few weeks when GI side effects are most prevalent B12: Often combined with GLP-1 agonists in compounded formulations, as semaglutide with B12 and tirzepatide with B12 combinations demonstrate Fiber: To support digestive regularity, which can be disrupted by altered gastric motility Biotin: Particularly if hair thinning occurs, as a preventive measure alongside adequate protein Exercise during retatrutide use Resistance training is more important than cardio during a GLP-1 protocol