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Even though this effect may be mediated by the insulin receptor, experimental KO mice for the insulin receptor gene show a potent glucose lowering effect of IGF-1, indicative that the hypoglycaemic effect is also mediated, in part, by its own IGF-1R

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Localization of GLP-1R in the TNC To localize the specific cell type for GLP-1R in the TNC, immunofluorescence was stained with Ibal-1 (microglial marker), GFAP (astrocytic marker) and NeuN (neuronal marker) using TNC sections in the CM group (Fig

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