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On one hand, p53 reduces cystine uptake by inhibiting SLC7A11 expression, leading to impaired function of GPX4, thereby inducing ferroptosis in lesioned chondrocytes to eliminate damaged cells

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The mechanistic trigger for loss of immune self-tolerance (which induces melanocytes apoptosis) is dysfunctional mitochondria resident in epidermal melanocytes (DellAnna et al., 2007) and also in CD8 + T cells (DellAnna et al., 2003)