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Accordingly, the proinflammatory potential of BPA has been pointed out as a mechanism of obesogenic disruption, activating proinflammatory signalling in fat cells by upregulating the expression and release of specific cytokines, such as CCL20, IL-18, IL-6, IL-1, and TNF- [174, 175]

The key factor here is bioavailability

Cantero-NavarroERayego-MateosSOrejudoMTejedor-SantamariaLTejera-MuozASanzABet alRole of macrophages and related cytokines in kidney disease

1 Incretins: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are the known incretin hormones from the upper (GIP, K cells) and lower (GLP-1, L cells) gut

Hodge AM, Simpson JA, Fridman M, Rowley K, English DR, Giles GG, Su Q, ODea K