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This rhythmic production and secretion of melatonin is driven by the SCN clock in the hypothalamus which integrates light signals via the retinohypothalamic tract to synchronize internal biological clocks with the external environment

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doi: 10.3389/fimmu.2026.1778455 Received 31 December 2025 Revised 20 March 2026 Accepted 26 March 2026 Published 22 April 2026 Volume 17 - 2026 Edited by Cyrus Khandanpour, University of Oldenburg, Germany Reviewed by Qun Zuo, Shanghai University of Sport, China Masaaki Mino, National Institute of Global Health and Medicine, Japan Updates Copyright 2026 Li, Chen, Zhou, Sun, Xing, Sun, Yang and Shi