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Results and discussion: Our study included 13 RCTs involving 5,838 participants with 3,794 ones in semaglutide group and 2,044 in placebo group

Injection site reactions: Pain, local tenderness , or swelling at the site of injection

Methylcobalamin, adenosylcobalamin and hydroxocobalamin are the three naturally occurring forms of B12

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The paw withdrawal latency (PWL) to heat was measured after either intraperitoneal or oral gavage administration of glucose (2.0 g/kg body weight) in a volume of 200 L or the same volume of vehicle (0.9% saline) ( n = 5 per group)