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The lipid-lowering effects appear to be indirect rather than through direct lipid metabolism

2 Materials and methods 2.1 Search strategy and data sources The systematic review and meta-analysis were conducted in accordance with the PRISMA 2020 guidelines (Kaku et al., 2018

Glu9 of the GLP-1 forms a direct hydrogen bond with Tyr152, an ionic interactions with Arg190, and a water mediated hydrogen bond with Tyr241

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