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2.3 Discontinuation for Iodinated Contrast Imaging Procedures Discontinue JANUMET at the time of, or prior to, an iodinated contrast imaging procedure in patients with an eGFR between 30 and 60 mL/min/1.73 m2

In more detail, enclomiphene interferes with the usual communication between the brain (specifically a part called the pituitary gland) and the gonads (ovaries in women, testes in men), which are all part of a system that controls hormone levels