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This matters because: Natural GH release is pulsatile (bursts followed by troughs) Continuous GH elevation can lead to receptor desensitization Pulsatile release maintains receptor sensitivity The pattern matches your body's circadian rhythm This is why timing and dosing frequency matter with Ipamorelinyou're working with your body's natural rhythms, not against them

doi: 10.1053/j.gastro.2016.10.012 137 GuntherCNeumannHNeurathMFBeckerC

The mechanism overlaps with the dopaminergic stimulation that drives insomnia