Not approved for human or animal use
Signal transduction pathways linking polyamines to apoptosis
For the typical adult carrying extra weight and otherwise healthy, the side effect story is mild, manageable, and mostly front-loaded into the first weeks
When GSH was depleted in vitro and in vivo , there was oxidative damage of complex I proteins (Chinta and Andersen, 2011), defects in basal ganglia formed (Sian et al., 1994), and the ubiquitinproteasome system functioned poorly (Martin and Teismann, 2009), but the electron transport chain complex was unaffected (Heales et al., Animal studies have also shown that excessive or reduced GSH levels can initiate degeneration of DA neurons (Garrido et al., 2000)
What is glutathione, and what does it do in the body