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59 Burg et al synthesized modified peptidomimetic glutathione analogs of these EAGSH compounds, which were hypothesized to be stabler against peptidase-mediated dissolution

Cell 2001

Tirzepatide (Zepbound) combines GLP-1 receptor agonism with glucose-dependent insulinotropic polypeptide (GIP) receptor agonism, creating a dual mechanism that affects multiple pathways