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Excessive or prolonged inflammation, however, can impair healing: chronic inflammatory signaling disrupts collagen organization, delays tissue maturation, and can convert an acute injury into a chronic condition

Initial laboratory test results were remarkable for an elevated lactate dehydrogenase level of 1097 U/L (normal range, 98-192 U/L), a uric acid level of 9.1 mg/dL (normal range, 3.0-6.8 mg/dL), an elevated serum creatinine level of 1.18 mg/dL (normal range, 0.44-1.03 mg/dL), and hypercalcemia with a serum calcium level of 1.7 mg/dL (normal range, 8.6-10.4 mg/dL)

The altered metabolome in this study provided new insight for understanding HCC, and the impact of the specific metabolites on the progression of HCC will be our next research work

doi: 10.1152/ajprenal.00259.2012