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Genetic causes include pathogenic variants in MMUT, MMAA, MMAB, and cobalamin-related genes (LMBRD1, ABCD4, MTRR), which contribute to MMA accumulation and further complicate the diseases clinical and biochemical heterogeneity [25, 26]

At-home programs may prescribe smaller doses (e.g., 100 mg ) injected subcutaneously (under the skin) on a more frequent schedule

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Why Gut Health Matters in Inflammation One of the biggest contributors to systemic inflammation is the gut