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Continued preclinical investigation will be necessary to clarify its mechanisms and determine what, if anything, this research model can reveal about broader tissue repair biology.

Immune systems

In our investigations, we observed that robust angiogenesis, characterized by grossly visible neovascularization and a marked increase in CD31-positive luminal structures by immunohistochemistry, was a prominent histological feature of healing in animal models of tissue injury treated with BPC157