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Given the limited regenerative capacity of neurons, sustained disruption of proteostasis progressively overwhelms cellular quality control systems, leading to synaptic dysfunction, neurodegeneration and irreversible cognitive or motor decline

114,166 Mutant p53 affects the mTOR signaling pathway by reducing the level of Beclin-1 phosphorylation to suppress autophagy

Because these validation experiments were performed with the entire phage set, we observed additional phage-enhancing effects of some counter-defense AGs in phage-host combinations that were omitted in the initial screen (Supplementary Fig

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