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Ipamorelins selective GHS-R1a agonism drives GH granule exocytosis from somatotrophs through Gq/11-PLC-IP3-calcium mobilisation , the identical intracellular signalling cascade engaged by non-selective first-generation GH secretagogues and but does so without producing the off-target receptor engagement at pituitary lactotrophs and corticotrophs that drives prolactin and cortisol co-secretion following GHRP-6 and GHRP-2 administration

10.1007/s00401-012-1038-9 Acta Neuropathol

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This is a textbook example of a complementary stack - three peptides doing three different jobs that add up to one result

This results in faster recovery times , reduced muscle soreness, and improved muscle function