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The NF-B signal can be triggered by multiple stimuli, including cytokines (e B pathway impairs protein C anticoagulation mechanism and promotes coagulation in endotoxemic mice

Conversely, when too much collagen is produced, hypertrophic or keloid scars develop, marked by raised, growth-like scars

10.1038/mp.2015.113 8 BattagliaD.KaragiannisA.GallopinT.GutchH

The study was conducted in strict accordance with institutional ethical guidelines and was approved by the Ethics Committee of Human and Animal Experiments at Rasht Branch, Islamic Azad University, Rasht, Iran (IR.IAU.RASHT.REC.1400.015)

This is the first genome-wide evaluation of the complex genetics of alopecia areata in any species