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Increased visceral adipocyte size is linked to adipose tissue dysfunction, inflammation, adipocyte apoptosis, systemic lipotoxicity and subsequent decline in metabolic parameters 67 - 69 whereas an increase in adipocyte size in subcutaneous adipose tissue is not

28(22) Chen T, Cheng L, Ma J, Yuan J, Pi C, Xiong L, Chen J, Liu H, Tang J, Zhong Y, Zhang X, Liu Z, Zuo Y, Shen H, Wei Y, Zhao L (2023) Molecular mechanisms of rapid-acting antidepressants: new perspectives for developing antidepressants

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In addition, longer follow-up may be needed to fully understand the long-term metabolic implications of these hormonal differences