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The absence of tissue growth effects also means AOD-9604 avoids many common side effects of growth hormone therapy including joint pain and swelling from connective tissue proliferation, carpal tunnel syndrome from tissue expansion, edema and fluid retention from protein synthesis and sodium retention, and concerns about growth-promoting effects in individuals with tumor history

Other effects seen in this combination are the increase of MGF mRNA and IGF-IE mRNA in older men, suggesting an enhancement of mechanical loading compared to resistance training alone (Sattler et al., 2009)

In TRIUMPH-4, retatrutide showed higher GI rates (nausea 43% vs 31%, vomiting 21% vs 12%)

Finkel T, Holbrook NJ

There is no defined dose for therapeutic use in humans in scientific literature