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In the Actos Now for Prevention of Diabetes (ACT NOW) study, pioglitazone decreased the rate of conversion of subjects from having impaired glucose tolerance (IGT) to T2DM by 72% and significantly improved insulin sensitivity and -cell function [30]

Olin KL, Golub MS, Gershwin ME, Hendrickx AG, Lonnerdal B, Keen CL

Using marker substrates to identify induction of specific P450s, Kreuger and coworkers provided a summary of sex and species differences in the magnitude of CYP enzyme induction

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NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates