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Mitochondrial chaperonins such as TRAP-1 also shape mitochondrial proteostasis and tumor metabolism

By analyzing BA composition, we found that the relative abundance of secondary BAs was significantly decreased in NASH mice, whereas HZRG intervention increased the percent of fecal secondary BAs (Figure 4B)

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The primary weight-loss endpoint was not met

When analyzed at an individual basis 60% of the Escitalopram treated animals were classified as drug-responders, which is in the range that we have observed repeatedly in previous studies 2