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Reduction in White Adipose Tissue Mass : Preclinical data indicate a marked reduction in white adipose tissue following administration of 5-Amino-1MQ

Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

NNMT inhibition increases availability of NAD+ and influences metabolic processes, allowing the body to burn more calories while suppressing additional glycogen and fat deposits

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