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In the lead-up to the migraine, alterations in the connectivity between the hypothalamus, brainstem, spinal trigeminal nuclei, and the dorsal rostral pons in the hindbrain have been noted as early as 48 h before the pain onset

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275 This provides an idea for treating PDAC by targeting the BCAA metabolism of CAF cells in the tumor environment and also proves that the tumor and various cells in the environment communicate with each other as a whole