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A Phase 3 diabetes trial is also ongoing as part of the submission package

Alcohol , especially excessive drinking and alcoholism, depletes folate [ R ] Niacin , high doses deplete methylation resources [ R ] Low stomach acid due to medications or other reasons can reduce folate absorption in the gut [ R ] Excessive SAM-e levels reduce MTHFR function [ R ] Smoking depletes folate [ R ] Chronic diseases/oxidative stress activate the enzyme GSK3B , which can inhibit MTHFR, especially in the presence of high SAM-e [ R ]