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GLP1 is a gut-derived polypeptide released from the intestinal L cells, capable of stimulating glucose-dependent insulin secretion and inhibiting food intake by acting on the pancreas and brain, respectively

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GIP (glucose-dependent insulinotropic polypeptide) - Enhances insulin secretion in response to food intake and helps prevent blood sugar spikes that can trigger hunger and cravings

In TRANSCEND-T2D-1 (type 2 diabetes): nausea 26.5%, diarrhea 22.8%, vomiting 17.6%, dysesthesia 4.4%