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She also cut gluten and dairy out of her diet and used other methods to lose weight, including functional medicine and surgery

Next, a metabolic-syndrome study reported higher energy expenditure, increased fatty-acid oxidation, reduced fat-mass accumulation, and improved insulin sensitivity in mouse models

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Semaglutide followed in the 2010s, initially for diabetes and later approved for weight loss based on landmark STEP trials showing up to 22% body weight reduction