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But I have found strong physiological and evidentiary reasons to introduce a GLP-1 RA before prandial insulin : GLP-1 RAs attenuate postprandial hyperglycemia through slowed gastric emptying , glucose-dependent insulin secretion , and glucagon suppression

When patients lose weight and their metabolism stabilizes, the body experiences less metabolic stress overall, which can indirectly reduce the demand for cortisol production

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Article PubMed Google Scholar Pechnick, R

Future studies are warranted to clarify the spatiotemporal mechanisms by which GLP-1GIPLani separates from GLP-1GIP co-agonism to further decrease body weight and food intake