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Although there are no standard criteria for the clinical and biomarker evidence required to support disease modification, clinical measures such as a change in trajectory of decline, an increasing drug versus placebo difference over time, an increased time to event, and an enduring change after discontinuation support this terminology

But these opportunities dont come without challenges, Evans warned

(AWARD-6) 3 A 26-week, randomized, open-label, parallel-group, multicenter (62 sites), multinational (9 countries), phase 3, noninferiority study

2018;23:2515690X18763294

Concurrently, lipid profiles (TG decreased by 40%, LDL by 22%) and blood pressure showed marked improvement