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Advanced experimental techniques, including spatial transcriptome, single-cell (or nuclei) transcriptomics and assay for transposase-accessible chromatin using sequencing, will be instrumental in uncovering the epigenetic and transcriptomic signatures associated with the transformation of astrocytes under neurodegenerative conditions 156

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233,298 As a representative cationic polymer, PEI is widely used in non-viral gene vectors in linear PEI (LPEI) or branched PEI (BPEI)

They may include nausea, headache, and blood pressure changes [31]

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