Griffith DA, et al
While the exact cause of SLE is unknown, it is believed to involve a combination of genetic, hormonal, and environmental factors, with individuals assigned female at birth and those of African American, American Indian, and Asian descent being at higher risk
Please note that using protein interactions as a selection criterion alone would yield 84 targets (Supplementary Data 5)
The calcium-binding affinity of S100 proteins is low in the absence of target proteins, but the affinity is significantly increased by several orders of magnitude in the presence of specific target proteins ( Figure 1 The 3D structures of S100 protein family have been resolved in three different states: Ca 2+ -free apo state, bound to Ca 2+ and bound to its target protein ( Because of multiple functions of the S100 proteins, many diseases, including psoriasis, are associated with altered expression levels of S100 proteins
Beneficial bacteria have long been studied in dogs and are routinely used in the treatment of gastrointestinal diseases