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The phase 2 dose-ranging trial (NCT02970942) included 320 individuals with histologically proven MASH and hepatic fibrosis F1-F3, randomizing them 3:3:3:1:1:1 to daily subcutaneous administration of semaglutide 0.1, 0.2, or 0.4 mg, or placebo for 72 weeks [18]
Medications known as glucagon-like peptide-1 receptor (GLP-1) agonists continue to rise in popularity thanks to their ability to help manage blood sugar levels and reduce hunger and food intake, thus potentially supporting weight loss
Diabetes 65 , 742754 (2016)
Rybelsus at the approved 14 mg daily dose, though, achieved just 4-5 percent in the PIONEER trials
Recommended starting dose: 3.4 grams (approximately one tablespoon or one standard dose of Metamucil) once daily
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