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The binding of insulin with IR causes autophosphorylation of IR [20, 21], activating downstream phosphoinositide-3-kinase (PI3-K)/Akt and mitogen activated protein kinase (MAPK) pathways, which affect the differentiation, energy metabolism and activity of osteocytes [22, 23]

This means your body can produce it naturally, even if you do not consume it directly through food

Thats where we are

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Oxidative stress can activate a variety of transcription factors including NF-B, AP-1, p53, HIF-1, PPAR-, -catenin/Wnt, and Nrf2