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These include the investigation of novel agents and optimal dosing strategies, assessment of long-term outcomes and safety profiles, evaluation of psychosocial impacts and strategies to promote health equity, and optimization of real-world implementation through combination therapies and digital health tools

PMCID: PMC3060373.

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Many compounds that bind receptors in a dish fail to produce meaningful effects in living organisms due to poor bioavailability, rapid metabolism, or insufficient tissue distribution