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NOS inhibition suppresses symptoms of withdrawal from nicotine (Malin et al., 1998), and acupuncture intervention to alleviate nicotine withdrawal-driven anxiety is correlated with reduced hypothalamic NOS activation (Liu et al., 2019)

However, the B12 itself can stay in your system longer, with effects on red blood cell production and nerve health lasting for weeks or months, depending on your deficiency and injection frequency

Liu, T., Zhang, L., Joo, D., & Sun, S

Serious side effects are rare at recommended doses, but users should monitor for any unusual symptoms and consult healthcare providers if concerns arise

The break is not required for safety or receptor resensitization, but it allows for reassessment and prevents indefinite use of a compound with limited long-term human data