doi:10.1093/carcin/bgs006, PMID: 22235026 Wachsman JT (1997) DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis
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Risk factors include age (usually affects people over 50), diabetes, hypertension, high cholesterol, sleep apnea, and anatomical predispositions such as a small cup-to-disc ratio