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Hace unos meses, la Agencia Espaola de Medicamentos y Productos Sanitarios (AEMPS) adverta de que este medicamento podra generar ceguera repentina , aunque se trataba de algo "muy infrecuente"

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Folate deprivation promotes mitochondrial oxidative decay: DNA large deletions, cytochrome c oxidase dysfunction, membrane depolarization and superoxide overproduction in rat liver