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The supernatant was aspirated and the cell pellet was suspended in supplemented DMEM media for further experiments

Participants had moderate to severe fibrosis (F2-F3), not cirrhosis (F4) A separate trial in patients with cirrhosis showed semaglutide didnt significantly improve fibrosis in that population Maintaining improvements likely requires ongoing weight management For fibrosis, about 37% of participants showed improvement of at least one stage

Nevertheless, many physicians still consider CPAP to be the gold standard treatment for OSA

Participants did not have Type 2 Diabetes (T2D) but did have Chronic Kidney Disease (CKD) which they defined as estimated glomerular filtration rate (eGFR) 25 and urine albumin-to-creatinine ratio (UACR) 30, they also had a body mass index 27 kg

Full metabolic adaptation typically occurs by week 1012 of consistent treatment