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The natural flavonoid fisetin induces apoptosis in HCT-116 colon cancer cells by inhibiting HSF1 binding to the HSP70 and BAG3 promoters, thereby suppressing the heat shock response and promoting cell death

Sulforaphane was the first identified and most potent naturally occurring NRF2 activator found in cruciferous vegetables such as broccoli, cauliflower, and Brussel sprouts (Zhang et al., 1992

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